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ThinkMind // COGNITIVE 2017, The Ninth International Conference on Advanced Cognitive Technologies and Applications // View article cognitive_2017_2_20_48011


A Neurochemical Framework to Stress and the Role of the Endogenous Opioid System in the Control of Heart Rate Variability for Cognitive Load

Authors:
Sergey Parin
Anna Polevaia
Sofia Polevaia

Keywords: endogenous opioid system; heart rate variability; cognitive function

Abstract:
This paper presents a complex analysis of the stress and shock phenomena. These specific reactions represent non-specific, protective, stepwise, multi-systemic, reduced psychophysiological responses to injury or threat. Finding psycho-physiological, neurochemical and patho-physiological mechanisms of stress and shock is an important task nowadays. It is relevant not only from the theoretical, but also from practical point of view, as every day thousands of people die from shock. At the beginning of 1980s, it has been suggested to look at stress and shock as processes based on similar mechanisms of hyperactivation of three neuro-endocrine systems: sympatho-adrenal system, hypothalamic-pituitary-adrenal axis and endogenous opioid system. The mechanisms of stress and shock are related to a significant reduction of regulatory mechanisms. On the basis of these theoretical concepts, we created an explicit psycho-physiological model of stress that describes in mathematical form, how neuro-endocrine input modulates cardiac responses during the first phase of stress reaction. Here, we give a comparative analysis of the heart-rate variability dynamics. This analysis was carried out for drug-addicts with reduction of endogenous opioid receptor apparatus, and for healthy volunteers in the context of cognitive loads of different levels. It is shown that such specific reactions as the reduction of the hart-rate autonomic regulation mode and the lack of adaptive variations in the heart-rate structure as response to the changing external information context, are typical for the examined drug-addicts.

Pages: 16 to 20

Copyright: Copyright (c) IARIA, 2017

Publication date: February 19, 2017

Published in: conference

ISSN: 2308-4197

ISBN: 978-1-61208-531-9

Location: Athens, Greece

Dates: from February 19, 2017 to February 23, 2017

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